Evaluation of Antioxidants in Bone Mineral Density of Iranian Osteoporotic Women

نویسندگان

  • Abdolazim Behfar Drug and Food Control Department, Faculty of Pharmacy, Jondishapoor University of Medical Sciences, Ahvaz, Iran
  • Behrooz Jannat Food and Drug Laboratory Research Center, Ministry of Health and Medical Education, Tehran, Iran
  • Mannan Hajimahmoodi Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  • Mohammad Reza Oveisi Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  • Molouk Hadjibabaie Pharmacotherapy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  • Naficeh Sadeghi Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
چکیده مقاله:

Objective(s) Bone is a dynamic tissue that is continuously renewed throughout life by the process of bone remodeling. Antioxidant system might be involved in the pathogenesis of bone loss, so the aim of this study was to evaluate the total antioxidant capacity (TAC), vitamin C and vitamin E levels of plasma besides measuring enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR) enzymes activity in Iranian osteoporotic women comparing to the control group. Materials and Methods Bone mineral density (BMD) of the femoral neck and lumbar spine was measured by dual x-ray absorptiometry. The participants were divided into groups: a) total participants (-3.9 ≤ T–score ≤ 3.6) including 192 women, b) the control group (T-score ≥ -1) including 76 women, c) the total patients (T-score < -1) including 76 women. Then, plasma TAC, vitamin C levels, SOD and GR activities, erythrocyte CAT were measured using spectrophotometrical methods separately, and for vitamin E by HPLC analysis. Results Comparing the control group and osteoporotic women showed that: a) plasma levels for vitamin C and erythrocyte CAT were markedly lower in the patients than in the controls, but plasma activity of TAC, SOD and GR were significantly higher, respectively. b) the differences were higher between control and patients with severe disease (T-score

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عنوان ژورنال

دوره 14  شماره 2

صفحات  158- 166

تاریخ انتشار 2011-03-01

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